Progesterone Gel is a medication used in hormone replacement therapy and in the treatment of certain gynecological conditions. Progesterone is a female hormone that plays a key role in regulating the menstrual cycle and preparing the uterus for pregnancy. Progesterone gel is usually applied topically to the skin, typically on the thigh, stomach, or upper arm. The dosage and duration of treatment may vary depending on the individual condition and response to the medication.